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目的:探讨突变型p53基因产物在胃癌中异常表达的意义。方法:应用免疫组织化学方法研究p53基因在98例胃癌中的表达。结果:98例胃癌标本中,p53表达阳性率为59.2％,与组织学类型无关;不同浸润深度胃癌与p53异常表达有关(P<0.05),肿瘤直径大于5cm者p53阳性率明显高于直径小于5cm者(P<0.01),在淋巴结转移组和无转移组间p53阳性程度有显著差异(P<0.01)。结论:p53异常表达是胃癌重要标志之一。
Objective: To investigate the significance of mutant p53 gene product abnormal expression in gastric cancer. Methods: The expression of p53 gene in 98 cases of gastric cancer was studied by immunohistochemistry. Results: The positive rate of p53 in 98 gastric cancer specimens was 59.2%, which was not related to the histological type. The different invasive depth of gastric cancer was correlated with the abnormal expression of p53 (P <0.05), and the positive rate of p53 was significantly higher than that of tumors with diameter> 5cm (P <0.01). There was a significant difference in the positive expression of p53 between lymph node metastasis group and non-metastasis group (P <0.01). Conclusion: Abnormal expression of p53 is one of the important markers of gastric cancer.