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目的检测各期重型肝炎患者血清细胞因子的水平,探讨细胞因子在重型肝炎发病中的作用机制及临床意义。方法设重型肝炎组和正常对照组,用酶联免疫吸附试验(ELISA)法测定每组患者血清中白细胞介素(IL)-2,IL-6,转化生长因子(TGF)β1,肿瘤坏死因子(TNF)-α,可溶性细胞凋亡因子(sFas),α-干扰素(IFN-α)的水平。结果各期重型肝炎患者血清细胞因子的水平与正常对照组之间差异均有显著性(P<0.05~0.001)。病情越重,IL-6,TGFβ1,TNF-α,sFas水平越高,而IL-2,IFN-α水平越低。结论血清IL-2,IL-6,TGFβ1,TNF-α,sFas,IFN-α的水平与肝细胞凋亡和坏死、损伤和修复以及病毒的复制之间存在内在联系,对评估重型肝炎的病情及预后有重要临床意义。
Objective To detect the levels of serum cytokines in patients with severe hepatitis and explore the mechanism and clinical significance of cytokines in the pathogenesis of severe hepatitis. Methods Serum levels of interleukin (IL) -2, IL-6, transforming growth factor (TGF) β1, tumor necrosis factor (TNF) and tumor necrosis factor (TNF) in serum of patients with severe hepatitis and normal controls were determined by enzyme-linked immunosorbent assay (ELISA) (TNF) -α, sFas, α-interferon (IFN-α). Results The levels of serum cytokines in patients with severe hepatitis were significantly different from those in the control group (P <0.05 ~ 0.001). The more serious the disease, the higher the levels of IL-6, TGFβ1, TNF-α and sFas, the lower the levels of IL-2 and IFN-α. CONCLUSIONS: The levels of serum IL-2, IL-6, TGFβ1, TNF-α, sFas and IFN-α are intrinsically related to the apoptosis and necrosis of hepatocytes, injury and repair and the replication of virus. And the prognosis has important clinical significance.