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目的观察贲门癌患者血浆Fibrinogen(FIB)水平与肿瘤临床分期、浸润程度和转移的关系,探讨其对于贲门癌患者的辅助诊断及判断预后的临床意义。方法结合临床资料,回顾分析使用美国贝克曼库尔特ACL8000型全自动凝血系列分析仪检测的我科收治的780例贲门癌患者的血浆中FIB含量。结果Ⅰ～Ⅳ期FIB(g/L)含量分别为(3.13±0.73)、(4.08±0.71)、(4.87±0.83)、(5.59±0.74)。T1～T4 FIB(g/L)含量分别为(3.16±0.69)、(3.59±0.74)、(4.52±0.75)、(5.47±0.68)。NOM FIB(g/L)含量分别为(3.21±0.60)、(4.17±0.43)、(5.06±0.72)、(5.59±0.74)差异均有统计学意义(P<0.05)。结论贲门癌患者存在FIB异常,且与临床分期成正相关。
Objective To observe the relationship between Fibrinogen (FIB) level and clinical stage, infiltration and metastasis of gastric cardia cancer and to explore the clinical significance of adjuvant diagnosis and prognosis of cardia cancer patients. Methods Combined with clinical data, the FIB content in plasma of 780 patients with cardia cancer treated by Beckman Coulter ACL8000 automatic blood coagulation analyzer was retrospectively analyzed. Results The contents of FIB (g / L) in stage Ⅰ ~ Ⅳ were (3.13 ± 0.73), (4.08 ± 0.71), (4.87 ± 0.83) and (5.59 ± 0.74), respectively. The contents of T1 ~ T4 FIB (g / L) were (3.16 ± 0.69), (3.59 ± 0.74), (4.52 ± 0.75) and (5.47 ± 0.68), respectively. The contents of NOM FIB (g / L) were (3.21 ± 0.60), (4.17 ± 0.43), (5.06 ± 0.72) and (5.59 ± 0.74) respectively, with statistical significance (P <0.05). Conclusion FIB abnormalities exist in patients with cardia cancer and have a positive correlation with clinical stage.