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目的:比较米非司酮合并米索前列醇与单纯阴道用米索前列醇终止10～12周妊娠的效果。方法:对102例孕10～12周要求终止妊娠的妇女,随机分成两种不同的治疗组。组Ⅰ:米非司酮配伍阴道用米索前列醇组62例,组Ⅱ:单纯阴道用米索前列醇组40例。结果:两组用药24 h内引产成功率,组Ⅰ为98.39%,组Ⅱ为87.50%,组Ⅰ明显高于组Ⅱ(P<0.05)。组Ⅰ首次阴道放药至胎儿、胎盘排出时间为(5.35±1.25)h,组Ⅱ为(10.42±3.37)h,组Ⅱ明显长于组Ⅰ(P<0.05)。结论:口服米非司酮75 mg合并阴道后穹窿放置米索前列醇用于终止10～12周妊娠,较单纯阴道放置米索前列醇的效果更加安全有效。
OBJECTIVE: To compare the efficacy of mifepristone with misoprostol and simple vaginal misoprostol for 10-12 weeks of gestation. METHODS: A total of 102 women who required termination of pregnancy from 10 to 12 weeks of gestation were randomly assigned to two different treatment groups. Group I: Mifepristone compatibility with misoprostol in vagina group of 62 cases, group II: simple vaginal misoprostol group of 40 cases. Results: The success rate of induction of labor within 24 h in both groups was 98.39% in group Ⅰ, 87.50% in group Ⅱ, and group Ⅰ was significantly higher than group Ⅱ (P <0.05). In group I, vaginal discharge was given to the fetus for the first time. The time of placenta discharge was (5.35 ± 1.25) h and group Ⅱ was (10.42 ± 3.37) h, and group Ⅱ was significantly longer than group Ⅰ (P <0.05). CONCLUSIONS: Oral mifepristone 75 mg combined with vaginal posterior fornix placed misoprostol for termination of 10-12 weeks pregnancy is more effective and safe than simple vaginal misoprostol placement.