【摘 要】
：
p27kip1是一种广谱的细胞周期蛋白依赖激酶(cyclin-dependent kinases,CDKs)抑制剂,主要通过抑制CDK的活性,来阻断细胞周期中G1/S期的转换,从而实现对细胞周期的负调控。p27
【机 构】
：
昆明医科大学基础医学院病理学与病理生理学系,
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p27kip1是一种广谱的细胞周期蛋白依赖激酶(cyclin-dependent kinases,CDKs)抑制剂,主要通过抑制CDK的活性,来阻断细胞周期中G1/S期的转换,从而实现对细胞周期的负调控。p27 kip1基因除了作为抑癌基因还有致瘤的潜能。这种双向性又在其亚细胞定位中体现,p27 kip1多个位点的磷酸化参与p27 kip1亚细胞定位的调控。这些研究可能对肿瘤的预后提示和治疗方面具有重要意义。本文就p27kip1亚细胞定位在肿瘤研究中的作用、磷酸化对p27kip1亚细胞定位的影响及p27kip1的研究对肿瘤治疗及预后方面的影响进行综述。
p27kip1 is a broad-spectrum inhibitor of cyclin-dependent kinases (CDKs) that blocks the G1 / S transition in the cell cycle primarily by inhibiting the activity of CDK, thereby achieving a negative effect on the cell cycle Regulation. In addition to the p27 kip1 gene as a tumor suppressor gene and tumorigenic potential. This bidirectionality, in turn, shows in its subcellular localization that phosphorylation at multiple sites of p27 kip1 is involved in the regulation of the localization of p27 kip1 subcellular localization. These studies may have important implications for the prognosis and treatment of tumors. This article reviews the role of p27kip1 subcellular localization in tumor research, the effect of phosphorylation on the localization of p27kip1 subcellular localization and the effect of p27kip1 on tumor therapy and prognosis.
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