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目的:探讨腔内给予比沙可啶对大鼠体外结肠运动模式的影响。方法:将19只雄性大鼠全结肠随机分为比沙可啶组和生理盐水组。在恒温浴槽内分别经结肠近端及远端腔内给予比沙可啶(bisacodyl)或生理盐水(0.9%NaCl),时空图记录分析离体结肠运动模式变化。结果:1比沙可啶近端灌注可引发簇集性长距离收缩(LDCs)(连续3-8个),频率为3/15 min;2比沙可啶远端灌注可引发规律LDCs,偶可见簇集性LDCs;30.9%NaCl灌注可引发节律性LDCs转换成缓慢推进的节律性运动,无簇集LDCs发生;4比沙可啶及0.9%NaCl灌注均使LDCs频率减低,但头端收缩运动增加。结论:比沙可啶腔内灌注可引发簇集性LDCs和独立的LDCs产生促进结肠传输;依运动模式特征推测神经源性机制起主要作用。
Objective: To investigate the effect of intradermic administration of bisacodyl on colonic motility in rats. Methods: The whole colon of 19 male rats were randomly divided into two groups: bisacodyl group and saline group. Bisacodyl or saline (0.9% NaCl) were administered into the proximal and distal colon respectively in the thermostatic bath, and the changes of isolated colon movement patterns were recorded by spatiotemporal mapping. RESULTS: Near-end bicortisidine perfusion induced clustered long-term contractions (LDCs) (3-8 consecutive) with a frequency of 3/15 min; 2-picracilidine perfusion induced regular LDCs and even clusters of visible clusters 30.9% NaCl perfusion induced the rhythmic LDCs to switch to slow-moving rhythmic movement, and no clustered LDCs occurred; 4 and 5% NaCl infused decreased the frequency of LDCs but increased the contractility of head-end. CONCLUSION: Intra-perfusion of bisacodyl can induce clustered LDCs and independent LDCs to promote colonic transit. The neurogenic mechanism may play a major role based on the characteristics of exercise patterns.