采用迪化糖锭（Ｄｉａｆｏｒｍｉｎ）治疗２０例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者，观察该药对血糖、血浆胰岛素浓度、红细胞膜胰岛素受体和红细胞膜流动性的影响。结果显示：①患者的血糖和血浆胰岛素浓度较治疗前降低；②胰岛素受体结合位点数显著增加，红细胞膜流动性显著升高。提示用Ｄｉａｆｏｒｍｉｎ后，ＮＩＤＤＭ患者的胰岛素受体结合位点增加，红细胞膜流动性改善，同时该药也发挥了降血糖作用。 Twenty patients with non-insulin dependent diabetes mellitus (NIDDM) were treated with Diaformin to observe the effects of the drug on blood glucose, plasma insulin concentration, erythrocyte membrane insulin receptor and erythrocyte membrane fluidity. The results showed that: (1) patients’ blood glucose and plasma insulin concentration decreased compared with those before treatment; (2) the number of insulin receptor binding sites increased significantly and the erythrocyte membrane fluidity increased significantly. Tip Diaformin, NIDDM patients with insulin receptor binding sites increased, improved erythrocyte membrane fluidity, while the drug also played a hypoglycemic effect.