苦参为豆科植物Sophora flavescens Ait的根。含有多种生物硷和黄酮类化合物。文献报告,苦参碱可降低过敏介质的释放,对速发型变态反应有明显的对抗作用。体外实验证实,其可以明显抑制小鼠T细胞的增殖及T_H细胞产生IL—2的能力。本实验拟就氧化苦参碱对小鼠激活的巨噬细胞吞噬功能的影响进行初步观察,进一步了解苦参生物硷对免疫系统的影响。 Sophora flavescens is the root of the legume Sophora flavescens Ait. Contains a variety of biological glycosides and flavonoids. The literature reports that matrine can reduce the release of allergic mediators and has a clear counteracting effect on immediate allergy. In vitro experiments confirmed that it could significantly inhibit the proliferation of mouse T cells and the ability of T_H cells to produce IL-2. In this experiment, preliminary observations were made on the effects of oxymatrine on phagocytosis of activated macrophages in mice, and further understanding of the effects of matrine on the immune system.