人骨形成蛋白 7(ｈＢＭＰ 7)最早由Ｃｅｌｅｓｔｅ等〔1〕克隆并命名。同年 ,Ｏｚｋａｙｎａｔ等〔2〕从人脑ｃＤＮＡ文库中也筛选出此克隆。以后研究表明 ,ＢＭＰ 7除了诱导成骨外 ,还具有广泛的生物学活性〔3 - 6〕。由于ｈＢＭＰ 7在神经系统及造血组织中的特殊作用 ,故其 Human bone morphogenetic protein 7 (hBMP 7) was first cloned and named by Celeste et al [1]. In the same year, Ozkaynat et al 〔2〕 from human brain cDNA library also screened this clone. Later studies have shown that BMP7 in addition to inducing osteogenesis, but also has a wide range of biological activity 〔3 - 6〕. Because hBMP 7 in the nervous system and hematopoietic tissue in a special role, so it