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目的探讨小剂量糖皮质激素吸入联合氨茶碱治疗轻中度哮喘患者的临床疗效。方法选取2013年1月至2015年1月中铁十七局集团中心医院收治的100例轻中度哮喘患者作为研究对象,按随机数字表法将其分为观察组和对照组,各50例。对照组患者应用吸入用布地奈德混悬液雾化吸入治疗,观察组患者采用吸入用布地奈德混悬液联合氨茶碱片进行治疗,比较两组患者的临床疗效、不良反应发生情况及治疗前后临床症状缓解情况。结果观察组患者不良反应发生率明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的PEF值明显高于对照组,发作次数明显少于对照组,持续时间明显短于对照组,差异均有统计学意义(均P<0.05)。结论小剂量糖皮质激素吸入联合氨茶碱治疗轻中度哮喘患者临床疗效明显,可减少糖皮质激素使用剂量,降低不良反应发生,安全性高,适合中长期使用。
Objective To investigate the clinical effect of low dose glucocorticoid inhalation combined with aminophylline in patients with mild to moderate asthma. Methods A total of 100 patients with mild to moderate asthma admitted to the Central Hospital of China Railway 17th Bureau Group from January 2013 to January 2015 were selected as study subjects and divided into observation group and control group according to random number table method, each with 50 cases in each group. Patients in the control group were treated with inhalation of budesonide suspension inhalation therapy. Patients in the observation group were treated with inhalation of budesonide suspension combined with aminophylline tablets. The clinical efficacy and adverse reactions of the two groups were compared Clinical symptoms before and after treatment to alleviate the situation. Results The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05). After treatment, the PEF values in the observation group were significantly higher than those in the control group, the number of attacks was significantly less than the control group, duration Significantly shorter than the control group, the differences were statistically significant (P <0.05). Conclusion Small doses of glucocorticoid inhalation combined with aminophylline in the treatment of mild to moderate asthma patients have obvious clinical efficacy, can reduce the dose of glucocorticoid, reduce the occurrence of adverse reactions, high safety, suitable for long-term use.