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目的研究五倍子等8种中药对多重耐药鲍曼不动杆菌体外抑制作用。方法选用肉汤稀释法,分析检测8种中药的水煎液对多重耐药鲍曼不动杆菌的体外抑菌活性。筛选抑菌效果最强的一种中药,比较其对鲍曼不动杆菌敏感菌株与多重耐药菌株抑菌活性。结果五倍子对多重耐药鲍曼不动杆菌有较强的抑菌作用,其次乌梅和丁香也有一定的抑菌作用,穿心莲、连翘、枸杞、黄芩、黄连均未表现出抑菌作用;五倍子对鲍曼不动杆菌多重耐药菌株和敏感菌株抑菌效果无区别。结论五倍子对多重耐药鲍曼不动杆菌有显著抑菌效果,具有开发前景。
Objective To study the inhibitory effects of 8 Chinese medicines, such as gallnut, on the multidrug-resistant Acinetobacter baumannii in vitro. Methods The broth dilution method was used to analyze the antibacterial activities of decoction of 8 kinds of Chinese herbs on multidrug-resistant Acinetobacter baumannii in vitro. Screening the strongest antibacterial effect of a traditional Chinese medicine, Acinetobacter baumannii sensitive strains and multi-drug resistant strains antibacterial activity. Results gallnut against multidrug-resistant Acinetobacter baumannii has a strong antibacterial effect, followed by plum and clove also have some antibacterial effect, andrographis, forsythia, wolfberry, skullcap, Coptis showed no antibacterial effect; gallnut Acinetobacter baumannii multi-drug resistant strains and sensitive strains no difference in antibacterial effect. Conclusion Galla had significant antibacterial effect on multidrug-resistant Acinetobacter baumannii, which has the prospect of development.