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观察Ｌ－精氨酸对大鼠常压低氧性肺动脉高压的预防和治疗作用。结果表明，Ｌ－精氨酸（２００ｍｇ／ｋｇ·ｄ）可明显预防低氧所致的肺动脉高压和右心室肥厚，Ｌ－精氨酸预防组平均肺动脉压（ｍＰＡＰ）（２．６１±０．０９ｋＰａ）明显低于低氧处理组（３．５８±０．０６ｋＰａ），两组间差异有显著性（Ｐ＜０．０５）；右心室／（左心室＋室间隔）重量比值（０．２６±０．０１）明显低于低氧组（０．３４±０．０１），两组间差异有显著性（Ｐ＜０．０５）。大鼠形成肺动脉高压后，经静脉灌注３００ｍｇ／ｋｇ的Ｌ－精氨酸可明显降低其ｍＰＡＰ，提示Ｌ－精氨酸对低氧性肺动脉高压可能具有一定的防治作用。
To observe the preventive and therapeutic effects of L-arginine on hypoxic pulmonary hypertension in rats. The results showed that L-arginine (200mg / kg · d) could obviously prevent pulmonary hypertension and right ventricular hypertrophy induced by hypoxia, and mean pulmonary arterial pressure (mPAP) in L-arginine prevention group (2.61 ± 0. (P <0.05). The weight ratio of right ventricle / (left ventricle + ventricular septum) was significantly lower than that in hypoxic group (3.58 ± 0.06 kPa) ± 0.01) was significantly lower than that in hypoxia group (0.34 ± 0.01), there was significant difference between the two groups (P <0.05). After the formation of pulmonary hypertension in rats, intravenous infusion of 300mg / kg L-arginine can significantly reduce its mPAP, suggesting that L-arginine may have some preventive and therapeutic effects on hypoxic pulmonary hypertension.