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目的:观察曲美布汀对肠易激综合征的临床疗效。方法:90例肠易激综合征病人随机分为两组,每组45例。治疗组用曲美布汀0.2g,每日3次;对照组用谷维素20mg,每日3次,维生素B120mg,每日3次;两组疗程均为4周。结果:治疗组退出1例,失访2例,42例完成疗程,显效26例、有效9例、无效7例,总有效率为83%(35/42)。对照组失访5例,40例完成疗程,显效10例、有效12例、无效18例,总有效率为55%(22/40)。两组显效率与总有效率比较差异均有统计学意义(P<0.002,P<0.01)。结论:曲美布汀治疗肠易激综合征有效。
Objective: To observe the clinical effect of Trimebutine on irritable bowel syndrome. Methods: 90 cases of irritable bowel syndrome patients were randomly divided into two groups, 45 cases in each group. The treatment group with trimebutine 0.2g, 3 times a day; control group with oryzanol 20mg, 3 times a day, vitamin B120mg, 3 times a day; two courses of treatment were 4 weeks. Results: In the treatment group, 1 patient was withdrawn and 2 patients were lost to follow-up. Of the 42 patients who completed the treatment, 26 were markedly effective, 9 were effective and 7 were ineffective. The total effective rate was 83% (35/42). Control group lost 5 cases, 40 cases completed the course of treatment, markedly effective in 10 cases, effective in 12 cases, 18 cases, the total effective rate was 55% (22/40). There was significant difference between the two groups in apparent efficiency and total effective rate (P <0.002, P <0.01). Conclusion: Trimebutine is effective in treating irritable bowel syndrome.