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目的：探讨早期肠内营养对重症颅脑损伤患者胃肠道功能的影响。方法重症颅脑损伤患者50例随机均分为实验组和对照组实验组于入院后24 h内给予匀速肠内营养乳剂（TP-HE）和肠内营养混悬液（百普力）。第1天予以肠内营养液的一半，若无明显不适反应则予以全量补充。对照组入院24 h内给予完全肠外营养（葡萄糖、脂肪乳、氨基酸、脂溶性及水溶性维生素），5~7d后逐渐改为肠内营养。比较两组在治疗后第1、7、14 d的体重、血清蛋白（ALB）、血红蛋白(Hb)、淋巴细胞总数（TLC）指标的变化，同时观察胃肠道反应。结果两组患者在体重方面均有所下降，但两组差异无统计学意义（P>0.05），而在治疗后第7、14 d，实验组在ALB、Hb、TLC均高于对照组（均P<0.05）。实验组在消化道不良反应发生的频次显著低于对照组（P=0.009），且消化道首次排便时间显著早于对照组。结论早期肠内营养能够很好地提供足够的营养支持，有效保护颅脑损伤患者的胃肠功能，降低胃肠道并发症的发生。“,”Objective To explore the effect of early enteral nutrition on the gastrointestinal function in patients with severe craniocerebral injury. Methods A total of 50 patients with severe craniocerebral injury were randomly divided into two groups, the observation group that received an early enteral nutrition support, and the control group used parenteral and enteral nutrition support sequential method. The weight, plasma albumin, hemoglobin and the total number of lymphocytes were assessed in day 7 and 14 between the two groups. Results A weight loss was observed of both groups with no significant difference. The plasma albumin, hemoglobin and lymphocytes in the observation group were markedly higher than those in the control group at day 7 and 14. Fewer complications were found in the observation group than the control group. Conclusion Early enteral nutrition could supply enough enteral nutrition and reduce the incidence of gastrointestinal complication.