论文部分内容阅读
[目的]评估同步新辅助放化疗治疗局部晚期乳腺癌的临床疗效和毒副作用。[方法]10例不可切除ⅢB期局部晚期乳腺癌在术前接受多西他赛联合表阿霉素同步放疗新辅助治疗,新辅助放化疗结束后2～3周手术,评价疗效与毒副作用。[结果]10例患者新辅助治疗后肿块缩小,均完成改良根治术,无一例皮瓣坏死。血液系统和消化道毒性反应较轻。无严重的神经系统以及心脏毒性反应。[结论]局部晚期乳腺癌患者联合化疗、手术与放疗可以显著提高局部治疗疗效,毒副作用可耐受。
[Objective] To evaluate the clinical efficacy and side effects of concurrent neoadjuvant chemoradiation in the treatment of locally advanced breast cancer. [Method] Ten patients with unresectable stage ⅢB locally advanced breast cancer were treated with docetaxel and epirubicin synchrotron radiation before operation. Neoadjuvant chemotherapy and toxicity were given after 2 ~ 3 weeks after the end of radiotherapy and chemotherapy. [Results] After the neoadjuvant treatment, all the 10 patients had the tumor reduced and the modified radical mastectomy was completed. No case of necrosis of the flap was found. Toxicity to the blood system and gastrointestinal tract is mild. No serious nervous system and cardiotoxic reactions. [Conclusion] Combined chemotherapy, surgery and radiotherapy can significantly improve the curative effect of local treatment in patients with locally advanced breast cancer, and the side effects can be tolerated.