研究表明,乙肝病毒的包膜蛋白HBsAg不仅可以作为疫苗的理想候选分子,还可作为基因工程疫苗的理想载体,用来成功构建多种重组核酸疫苗。本文概述了以乙肝表面抗原为载体,重组或联合其他病毒、寄生虫、细胞因子等其他基因制作多价核酸疫苗的研究进展。 Studies have shown that hepatitis B virus HBsAg is not only an ideal candidate for vaccine, but also an ideal carrier for genetic engineering vaccines for successful construction of a variety of recombinant nucleic acid vaccines. This article summarizes the research progress of hepatitis B surface antigen as a carrier, recombinant or in combination with other viruses, parasites, cytokines and other genes to produce multivalent nucleic acid vaccine.