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腹膜透析是终未期肾脏病的有效治疗方法之一,长期的连续不卧床腹膜透析患者,腹膜会有大量的细胞外基质沉积和新生血管形成即发生了腹膜纤维化,将导致超滤衰竭。细胞因子在腹膜纤维化中起了重要作用。转化生长因子可引起腹膜间皮细胞向成纤维细胞转分化,间皮细胞的转分化是腹膜纤维化的重要机制;血管内皮生长因子是引起腹膜新生血管形成的重要因子;炎症因子、血管紧张素II在腹膜纤维化中亦起一定作用。
Peritoneal dialysis is one of the most effective treatments for end-stage renal disease. Long-term continuous ambulatory peritoneal dialysis patients suffer from peritoneal fibrosis due to a large number of extracellular matrix deposits and neovascularization in the peritoneum, leading to failure of ultrafiltration. Cytokines play an important role in peritoneal fibrosis. Transforming growth factor can cause transdifferentiation of peritoneal mesothelial cells to fibroblasts, and the transdifferentiation of mesothelial cells is an important mechanism of peritoneal fibrosis. Vascular endothelial growth factor is an important factor that causes peritoneal neovascularization. Inflammatory factors, angiotensin II also plays a role in peritoneal fibrosis.