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[目的]探讨肿瘤坏死因子(TNF-α)水平对Ⅰ型糖尿病患儿发病中的作用。[方法]应用酶联反应法对42例Ⅰ型糖尿病患儿及24例健康儿童测定TNF-α水平进行测定。[结果]Ⅰ型糖尿病患儿与健康儿童比较,空腹血糖明显高于健康儿童(P<0.01),而TNF-α水平亦明显高于健康儿童(P<0.05)。[结论]TNF-α对Ⅰ型糖尿病患儿发病可能有一定的内在联系。
[Objective] To investigate the role of tumor necrosis factor (TNF-α) in the pathogenesis of type 1 diabetes in children. [Methods] The levels of TNF-α in 42 children with type 1 diabetes mellitus and 24 healthy children were measured by enzyme-linked reaction. [Result] Compared with healthy children, the fasting blood glucose of type I diabetic children was significantly higher than that of healthy children (P <0.01), while the level of TNF-α was also significantly higher than that of healthy children (P <0.05). [Conclusion] TNF-α may have a certain intrinsic relationship with the onset of type 1 diabetes in children.