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为了筛选抗亚硝胺致癌作用的化学预防药物,通过亚硝基肌氨酸乙酯诱发小鼠前胃鳞癌的药物阻断试验结果发现,九种维生素的抑制率为21.06％,维酶素为26.68％,两种营养阻断剂均未见明显的阻断癌变的预防作用(P>0.05)。而加有亚硝胺阻断剂的强化维酶素和具有抗致突作用的中药R均有明显的阻断癌变的预防作用,其抑制率分别为55.58％(P<0.01)和63.64％(P<0.01)。并可明显地提高NK细胞和SOD活性,具有增强细胞免疫和解毒功能。为食管癌的病因学预防研究提供了科学依据和有效的苗头预防药物。
In order to screen for chemopreventive drugs against nitrosamine carcinogenesis, the drug blockade test of mice prodromal squamous cell carcinoma induced by ethyl nitrostoramosulfate showed that the inhibition rate of nine vitamins was 21.06%. At 26.68%, no significant blockade of the cancer-preventing effect was observed with either of the two nutrient blocking agents (P>0.05). On the other hand, reinforcing riboflavin with nitrosamine blockers and traditional Chinese medicine R with anti-irritability all had significant preventive effects against canceration. The inhibition rates were 55.58% (P<0.01) and 63.64% (respectively). P<0.01). It can significantly increase the activity of NK cells and SOD, and has the functions of enhancing cellular immunity and detoxification. It provides scientific basis and effective preventive medicine for the etiological prevention research of esophageal cancer.