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目的总结妊娠期合并鼻咽恶性肿瘤患者的临床资料,探讨妊娠期合并鼻咽恶性肿瘤的临床特点,以达到早期诊断、早期治疗的目的。方法以2007年9月至2012年7月收治的妊娠期合并鼻咽恶性肿瘤5例作为研究对象。其中鼻咽鳞状细胞癌4例,鼻咽恶性肌上皮瘤1例。回顾分析患者的临床表现、诊断结果及治疗情况,并对患者及其子代进行随访。结果 5例患者均为单胎妊娠,3例(60.00%)在妊娠过程中活检确诊后终止妊娠行引产术,2例(40.00%)为妊娠中发病,分别于产后1周和产后1个月活检确诊。新生儿健康存活。鼻咽鳞状细胞癌患者均采用同期放化疗,鼻咽恶性肌上皮瘤患者采用经鼻内镜及软腭联合径路手术治疗,术后1周辅助放疗。结论妊娠期合并鼻咽恶性肿瘤较为少见,合并鼻咽恶性肌上皮瘤更为罕见。妊娠期由于检查及用药的局限性,容易出现漏诊及误诊。治疗应根据肿瘤性质、分期、患者意愿等因素综合考虑,并对患者及子代做长期随访。
Objective To summarize the clinical data of patients with nasopharyngeal malignant tumor in pregnancy and discuss the clinical features of nasopharyngeal malignant tumor in pregnancy in order to achieve the purpose of early diagnosis and early treatment. Methods From September 2007 to July 2012, 5 cases of nasopharyngeal malignant tumor complicated with pregnancy were studied. Including nasopharyngeal squamous cell carcinoma in 4 cases, 1 case of nasopharyngeal malignant myoepithelioma. Retrospective analysis of the patient’s clinical manifestations, diagnosis and treatment, and patients and their offspring were followed up. Results All 5 patients were singleton pregnancies. Three patients (60.00%) were induced termination of pregnancy by biopsy during pregnancy, and 2 cases (40.00%) were pregnant during pregnancy, 1 week postpartum and 1 month postpartum Biopsy confirmed. Newborn healthy survival. Nasopharyngeal squamous cell carcinoma patients were treated with concurrent chemoradiotherapy, nasopharyngeal malignant myoepithelioma by endoscopic and soft palate combined with pathological surgery, adjuvant radiotherapy after 1 week. Conclusions Pregnancy complicated with nasopharyngeal malignant tumors is rare, with nasopharyngeal malignant myoepithelioma more rare. Due to the limitations of pregnancy check and medication, prone to missed diagnosis and misdiagnosis. Treatment should be based on the nature of the tumor, staging, the patient’s wishes and other factors considered, and patients and their offspring to do long-term follow-up.