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氨苄青霉素(ampicillin)是广泛应用于临床的广谱半合成青霉素,主要用于治疗呼吸道感染、泌尿系感染、化脓性脑膜炎、败血症等疾病。鉴于国内仅有静脉应用氨苄青霉素药动学的研究报道,本文针对新生儿感染性疾病肌注氨苄青霉素进行药物动力学研究,为临床合理用药提供科学依据。 对象与方法 本文研究对象为1991年2月～4月患感染性疾病的住院患儿共6例,日龄15～34天,男女比为1∶1,体重2.1～3.1kg,无肝肾功能不良表现。标本的收集:患儿以100mg/kg剂量肌注氨苄青霉素。于注射后0.25、0.5、1、2、4、8小时采集足
Ampicillin is a broad-spectrum semisynthetic penicillin widely used in the clinic, mainly for the treatment of respiratory tract infections, urinary tract infections, purulent meningitis, sepsis and other diseases. In view of the domestic only intravenous ampicillin pharmacokinetic studies reported, this article intramuscular ampicillin for neonatal infectious disease pharmacokinetic study for clinical rational use of drugs provide a scientific basis. Subjects and Methods The subjects of this study were 6 hospitalized children with infectious diseases from February to April in 1991, with a mean age of 15-34 days. The male-to-female ratio was 1: 1 and the body weight was 2.1-3.1 kg. Bad performance. Collection of specimens: The children were intramuscularly ampicillin at a dose of 100 mg / kg. At 0.25, 0.5, 1, 2, 4, 8 hours after injection, feet were collected