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利用抗肿瘤相关抗原的抗体对肿瘤进行导向定位、治疗已引起医学界的普遍关注。核素标记的抗肝癌单抗的研究始于近年,国内尚无完整报道。本文用~(131)I标记的抗人肝癌单抗在裸鼠人肝癌模型上进行肿瘤定位,并分析了影响定位的因素及进一步改进的途径。
The use of antibodies against tumor-associated antigens to guide the localization and treatment of tumors has caused widespread concern in the medical community. The study of radiolabeled anti-hepatocarcinoma monoclonal antibody started in recent years and there is no complete report in China. In this study, tumor-targeting of human anti-human hepatocellular carcinoma monoclonal antibody labeled with 131I was performed on nude mice and the factors influencing localization and further improvement were analyzed.