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本研究用左侧大脑中动脉平均血液流速及相应血管阻力的变化探讨了天麻钩藤饮的体内临床药效动力学过程与参数。结果天麻钩藤饮能增加其流速并降低其阻力，且在一定剂量范围内呈量效关系。天麻钩藤饮对左侧大脑中动脉平均血液流速作用的最低起效剂量为０１６ｇ／ｋｇ，相当于临床等效剂量的效应消退半衰期为１７２小时，消除速率常数为０４０，效应维持时间为６０８小时；降低血管阻力作用的最低起效剂量为０１９ｇ／ｋｇ，其余相应为２６２小时，０２６和８６１小时
In this study, the in vivo clinical pharmacodynamics and parameters of Tianma Gouteng Decoction were investigated using the mean blood flow velocity of the left middle cerebral artery and the corresponding changes in vascular resistance. Results Tianma Gouteng Decoction can increase its flow rate and reduce its resistance, and showed a dose-effect relationship within a certain dose range. The minimum dose of effect of Tianma Gouteng Decoction on the mean blood flow velocity of the left middle cerebral artery was 016g/kg, which was equivalent to the clinically equivalent dose effect half-life of 172 hours, and the elimination rate constant was 040. The effect maintenance time was 608 hours; the minimum effective dose to reduce vascular resistance was 019g/kg, and the rest was 262 hours, 026 and 861 hours.