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目的:观察千金子生品和不同含油量的千金子霜对小鼠炎性腹水病理模型的影响,探讨千金子制霜的目的和千金子霜合理的含油量标准。方法:腹腔注射0.6%的醋酸造成小鼠炎性腹水病理模型,观察各给药组2h、4h、6h和8h不同时段小鼠体重的变化。结果:千金子生品0.26g/kg和1.3g/kg在各时段利尿作用均不明显,与模型组比较无明显的统计学差异。含油量22.3%和25%的千金子霜高剂量组(0.65g/kg)体重减轻程度相对较大,各时段与模型组比较具有较显著地统计学差异(P<0.05)。含油量25%低剂量(0.13g/kg)组在8h时体重减轻与模型组比较也有显著性差异(P<0.05),而28.4%含油量的霜高、低剂量组体重减轻均不明显。结论:千金子制霜后减轻炎性水肿作用比生品明显增强,含油量22.3%～25%的千金子霜作用最为明显。
OBJECTIVE: To observe the effects of Qianjinzi and Qianjinzi Cream with different oil content on the pathological model of inflammatory ascites in mice, and to explore the purpose of Qianjinzi Cream and the reasonable oil content standard of Qianjinzi Cream. Methods: The intraperitoneal injection of 0.6% acetic acid caused inflammatory ascites pathological model in mice. The body weight of mice in each group was observed at 2h, 4h, 6h and 8h. Results: The results showed that 0.26g / kg and 1.3g / kg did not have obvious diuretic effect in each time period, and no significant difference compared with model group. The 22.3% and 25% oily gold cream high dose group (0.65g / kg) weight loss is relatively large, each period compared with the model group has a statistically significant difference (P <0.05). Compared with the model group, the body weight loss of the 25% low-dose (0.13g / kg) group of 25% oil content was significantly different (P <0.05), while the weight loss of 28.4% oil-rich cream group and low dose group was not obvious. CONCLUSION: The effect of alleviating inflammatory edema after milking cream was significantly enhanced than that of crude product. The effect of millet frost with oil content of 22.3% ~ 25% was the most obvious.