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本实验成功地将人子宫内膜植入到15只去卵巢新西兰雌兔的眼前房,并给每只兔外源补充雌二醇(E2)100μg/d和孕酮(P)8mg/d。在内膜植入期间每只兔皮下注射总量为9mg的霉酚酸(my-cophenolicacid)以防免疫排斥反应。在眼前房的人子宫内膜存活了28.44±8.65天,兔血清E2和P的平均值分别为161.71±15.13和38.88±7.45pmol/L。前房液中E2和P浓度在植入人子宫内膜前后分别为24.80±16.53和1709.25±475.10pmol/L,2.00±0.53和12.22±3.81nmol/L。树脂切片验证人子宫内膜植入兔眼前房第5天就能与虹膜附贴并有血管发生。来自巩膜的血管分布在子宫内膜周围。扫描电镜观察人子宫内膜分化成分泌细胞和纤毛细胞。植入人子宫内膜后,前房液的蛋白浓度高于植入前。可以证明该模型可用来研究人子宫内膜对药物的反应和通过对前房液的测量研究子宫内膜的分泌功能。
In this study, human endometrium was successfully implanted in the anterior chamber of 15 ovariectomized New Zealand female rabbits and each rabbit was exogenously supplemented with 100 μg estradiol (E2) and 8 mg / d progesterone (P). A total of 9 mg of my-cophenolic acid was injected subcutaneously into each rabbit during endomembrane implantation to prevent immune rejection. In the anterior chamber of the human endometrium survived 28.44 ± 8.65 days, the average serum E2 and P were 161.71 ± 15.13 and 38.88 ± 7.45pmol / L. E2 and P concentrations in anterior chamber fluid were 24.80 ± 16.53 and 1709.25 ± 475.10 pmol / L, 2.00 ± 0.53 and 12.22 ± 3 before and after implantation into human endometrium, respectively. 81 nmol / L. Resin slice testers endometrial implantation rabbit anterior chamber of the eye can be attached with the iris on the 5th day and have angiogenesis. Blood vessels from the sclera are distributed around the endometrium. Human endometrium was differentiated into secretory cells and ciliated cells by scanning electron microscopy. After implantation of human endometrium, the concentration of protein in the aqueous humor was higher than that before implantation. It can be shown that the model can be used to study the response of human endometrium to drugs and to study the secretory function of the endometrium by measuring the fluid in the anterior chamber.