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[目的]探讨妇科千金片抑菌作用机制。[方法]通过体外对大肠埃希菌、金黄色葡萄球菌、白色念珠菌和铜绿假单胞菌抑菌试验及体内对金黄色葡萄球菌感染小鼠的保护作用试验,观察妇科千金片抑菌作用。[结果]体外抑菌试验表明,妇科千金片对大肠埃希菌(最小抑菌浓度为37.50mg/mL)、金黄色葡萄球菌(最小抑菌浓度为75.00mg/mL)、白色念珠菌(最小抑菌浓度18.75mg/mL)和铜绿假单胞菌(最小抑菌浓度37.50mg/mL)有抑制作用,体内抑菌实验表明,妇科千金片(1.65g/Kg)有降低金黄色葡萄球菌感染小鼠死亡率的作用,表明本品有抑菌作用。[结论]妇科千金片具有抑菌的作用。以上结果为妇科千金片临床应用提供了药效学依据。
[Objective] To explore the antibacterial mechanism of Qianqimian tablets. [Method] The antibacterial activity of Escherichia coli, Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa in vitro and the protective effect in vivo on Staphylococcus aureus-infected mice were observed. . [Results] The antibacterial activity in vitro showed that the antibacterial activity of Gynecology Qianjin tablets against Escherichia coli (minimum inhibitory concentration 37.50mg / mL), Staphylococcus aureus (minimum inhibitory concentration 75.00mg / mL), Candida albicans Bacteriostatic concentration 18.75mg / mL) and Pseudomonas aeruginosa (minimum inhibitory concentration 37.50mg / mL) inhibition, in vivo antibacterial experiments showed that gynecology daughter (1.65g / Kg) have reduced Staphylococcus aureus infection The role of mouse mortality, indicating that the product has antibacterial effect. [Conclusion] Gynecology Qianjin tablets have antibacterial effect. The above results provide a pharmacodynamic basis for the clinical application of gynecological daughter gold tablets.