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本研究旨在判断部分纯化的α干扰素对毛细胞白血病(HCL)患者的临床效用。治疗的7例HCL患者中,男6例,女1例,年龄26-51岁(中位数39岁)。HCL的诊断根据临床特征和在外周血、骨髓或组织标本中出现典型毛细胞作出。7例中5例于α干扰素治疗前6-48月作过脾切除,其中2例以后作过化疗,1例用卡介苗甲醇抽提残余物作过免疫治疗。其余2例未治。所有患者均为以前治疗失败或有进行性疾病证据者。用标准的血液学方法评定疗效。每4-12周在髂嵴的多个部位作骨髓检查。所用α干扰素的比活性为1×10~6U/mg蛋白,所有患者在门诊每日肌注3×10~6U。
This study aimed to determine the clinical utility of partially purified interferon alpha in hairy cell leukemia (HCL) patients. Among the 7 HCL patients treated, 6 were males and 1 females, aged 26-51 years (median, 39 years). The diagnosis of HCL is based on clinical features and the appearance of typical hair cells in peripheral blood, bone marrow or tissue specimens. Five of the seven patients underwent splenectomy 6 to 48 months prior to interferon alpha treatment, two of whom were subsequently treated with chemotherapy and one of whom was immunized with BCG methanol extract. The remaining two cases were not cured. All patients were previously treated failed or evidence of progressive disease. The standard hematology method to assess the efficacy. Bone marrow examination was performed at multiple sites of the iliac crest every 4-12 weeks. The specific activity of interferon alpha used was 1 × 10-6 U / mg protein, and all the patients received daily intramuscular injection of 3 × 10-6 U in the clinic.