[目的]探讨消化道印片细胞学镜下背景对恶性肿瘤诊断的临床意义。[方法]电子胃镜检查并取黏膜组织印片,作细胞学检查。[结果]消化道恶性肿瘤黏膜组织印片镜下背景可见癌性坏死,与炎性疾病时背景不同。[结论]消化道印片细胞学检查背景的分析判断有助于提高消化道恶性肿瘤的检查准确率,可以作为细胞学检查判断的一个指标。 [Objective] To investigate the clinical significance of gastrointestinal endoscopy in the diagnosis of malignant tumors. [Methods] Electron gastroscopy and mucosal tissue prints were taken for cytological examination. [Results] The cancerous necrosis was found in the background of gastrointestinal malignant tumor mucosa printed film, which had different background with inflammatory disease. [Conclusion] The analysis and judgment of the background of digestive tract printing cytology can help improve the accuracy of the examination of gastrointestinal malignancies, which can be used as an indicator of cytological examination.