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为了解我国不同地区呼吸道合胞病毒（ＲＳＶ）感染特征是否与基因变异有关，对北京、广州、长春和河北四个地区不同流行特征中分离的ＲＳＶ毒株（Ａ亚型）的Ｇ蛋白基因进行了序列分析。结果表明，该Ｇ蛋白基因同国外Ａ亚型原型株（Ａ２株）间存在显著差异，Ａ２株同分离株间的核苷酸同源性为９２．７％～９３．６％，氨基酸同源性只有８８．３％～８９．９％。分离株间的核苷酸同源性为９６．０％～９８．９％，氨基酸同源性９２．６％～９７．７％。氨基酸变异主要集中在胞外区一个高度保守区的两端，而胞内区和跨膜区相对保守。同Ａ２株比较，我国ＲＳＶ分离株间氨基酸的变异位点和变异形式很近似。结果提示，由于我国ＲＳＶ分离株Ｇ蛋白基因同国外原型株间存在明显差异，因此在研制我国ＲＳＶ疫苗时可考虑采用我国的ＲＳＶ分离株；我国ＲＳＶ的不同流行特征可能并非由于ＲＳＶＧ蛋白的变异所致。
To understand whether the characteristics of respiratory syncytial virus (RSV) infection in different regions of our country are related to genetic variation, the G protein gene of RSV strain (A subtype) isolated from different epidemic characteristics in Beijing, Guangzhou, Changchun and Hebei was investigated Sequence analysis. The results showed that there was a significant difference between the G protein gene and the foreign subtype A subtype (A2 strain). The nucleotide homology between isolates of A2 strain was 92.7% -93.6%, amino acid homology Sex is only 88.3% ~ 89.9%. Nucleotide homology between the isolates was 96.0% ~ 98.9%, amino acid homology 92.6% ~ 97.7%. Amino acid variation mainly concentrated in the extracellular region of a highly conserved region at both ends, while the intracellular and transmembrane region is relatively conservative. Compared with the A2 strain, the amino acid variation sites and variations among RSV isolates in China are similar. The results suggest that due to the significant difference between the G protein gene of Chinese RSV isolates and foreign prototype strains, we may consider using RSV isolates in our country to develop the RSV vaccine. The different epidemiological features of RSV in our country may not be due to the RSV-G protein Variation caused.