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在研究甲状旁腺疾病中,甲氰咪胍是一种很有价值的药物。已经证明组织胺可以刺激PTH和cAMP产生,这种作用又可被组胺H_2-受体阻断剂甲氰咪胍所抑制。另外,甲氰咪胍还可使甲状旁腺内部的PTH肽键重新组台。通过对甲状旁腺内H_2-受体的鉴定,认为在甲旁亢时,组胺H_2-受体也有其相应的反应,在临本上,甲氰咪胍对高钙血症的生物效应巳为人们所重视。治疗因甲状旁腺腺瘤所致的甲旁亢时,目前推荐的剂量为1500-2400mg/日,与治疗卓一艾氏综合征者相同,但大於消化性溃疡的治疗量。
In the study of parathyroid disease, cimetidine is a valuable drug. Histamine has been shown to stimulate the production of PTH and cAMP, which in turn can be inhibited by histamine H 2 -receptor blocker cimetidine. In addition, cimetidine can also reorganize the PTH peptide bonds inside the parathyroid glands. Through the identification of H 2 -receptor in the parathyroid gland, it is thought that in the hyperparathyroidism, the histamine H 2 -receptor also has its corresponding reaction. In the clinical case, the biological effect of cimetidine on hypercalcaemia Pay attention to people. Treatment of hyperparathyroidism due to parathyroid adenoma, the current recommended dose of 1500-2400mg / day, and the treatment of a Ezhyll’s syndrome were the same, but greater than the treatment of peptic ulcer.