论文部分内容阅读
目的了解玉溪市2009-2014年流感流行特征和流感流行优势毒株的变化规律,为制定预防和控制策略提供依据。方法采用MDCK细胞进行流感样病例标本的病毒分离培养,最后采用流感分型试剂进行病毒型别鉴定。结果2009-2014年玉溪市流感实验室共监测流感样病例3 248例,阳性标本489份,阳性率为15.06%,新甲型H1N1、H3N2、B型流感分别占43.97%、28.22%和25.36%,学生和离退人员阳性病例分别占52.15%和14.11%;哨点医院流感样病例标本阳性检出率低于暴发疫情,差异有统计学意义(χ2=301.14,P<0.01);每年10月到次年3月出现流行高峰,2009年10月至2011年3月以新甲型H1N1流感为主,2011年4月至2012年3月以B型流感为主,2012年4月至2013年3月以A(H3N2)型流感为主;2013年4月至2014年3月以B型流感为主。结论玉溪市流感病毒优势毒株是甲型H1N1、H3N2、B型流感,优势毒株在2009-2014年发生了四次转变,其进一步变异的可能性仍然存在,加强流感样病例病原学与重点人群疫情监测有重要意义。
Objective To understand the epidemiological characteristics of influenza and the prevalence of influenza pandemic strain in Yuxi City from 2009 to 2014 and provide evidence for the development of prevention and control strategies. Methods MDCK cells were used for virus isolation and culture of influenza-like cases. Finally, influenza type reagents were used to identify the virus types. Results A total of 3 248 flu-like cases were detected in the influenza laboratory of Yuxi City from 2009 to 2014, with 489 positive samples, the positive rate was 15.06%. Influenza A H1N1, H3N2 and B influenza accounted for 43.97%, 28.22% and 25.36% respectively, (52.15% and 14.11%) respectively. The positive rate of influenza-like cases in sentinel hospitals was lower than that of outbreaks (χ2 = 301.14, P <0.01). Each year in October The peak of the epidemic occurred in March of the following year. The influenza A (H1N1) virus was mainly reported from October 2009 to March 2011, while influenza B was mainly reported from April 2011 to March 2012, and from April 2012 to 2013 In March, influenza A (H3N2) was the mainstay; in April 2013 to March 2014, influenza B was the mainstay. Conclusion The predominant strains of influenza virus in Yuxi are Influenza A H1N1, H3N2 and Influenza B strains. The dominant strains have undergone four transformations in 2009-2014, and the possibility of further mutation still exists. Streptococcus flu-like pathogens and emphasis Population epidemic monitoring is of great significance.