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吡喹酮治疗慢性血吸虫病一般采用总剂量60mg/kg(体重不足30kg,70mg/kg)二天四次分服。但是,临床实践表明,此法治疗儿童血吸虫病,阴转率较成人稍低。所以,国内不少学者对吡喹酮治疗儿童血吸虫病的疗程和剂量进行了一些研究,一般认为其剂量可考虑略高于成人。但是,究竟需要增加多少剂量及可否提高疗效则意见不尽一致,为探索儿童血吸虫病的适宜治疗剂量,我们在现场进行了比较观察。临床资料一、治疗对象:在我县血吸虫病流行区,治疗前半个月用改良加藤氏法(Kato法)对当地初一学生、小学生和少数未上学儿童进行粪便检查,每份粪样敛4张涂片~6,阳性者做虫卵计数并计算克粪虫卵数(EPG)作为治疗对
Praziquantel treatment of chronic schistosomiasis is generally used a total dose of 60mg / kg (weight less than 30kg, 70mg / kg) four times a day for four times. However, clinical practice shows that this method of treatment of schistosomiasis in children, negative conversion rate slightly lower than adults. Therefore, many domestic scholars on praziquantel treatment of children schistosomiasis treatment and dose of some research, the general view that the dose may be considered slightly higher than adults. However, there are different opinions on whether the dosage should be increased or whether the therapeutic effect can be improved. To explore the appropriate therapeutic dose of schistosomiasis in children, we conducted a comparative observation in the field. Clinical data First, the treatment of: In our county schistosomiasis endemic areas, half a month before treatment by improved Kato’s method for local first-year students, pupils and a few non-school children stool examination, each fecal samples convergence 4 Zhang smear ~ 6, were positive for egg count and calculate the number of grams of fecal eggs (EPG) as a treatment