抗菌药物的血浆蛋白结合力是影响药物药代动力学和药效学两参数的一个极为重要的因素。因此,详细了解药物进入体内后与血浆蛋白的结合力是必要的,本研究采用类似于体内环境(肾脏内药物排泄)的超滤技术及HPLC法检测技术测定了临床和实验研究的许多促旋酶抑制剂以及它们的相似物 Antibacterial plasma protein binding is one of the most important factors affecting pharmacokinetics and pharmacodynamics. Therefore, it is necessary to know in detail the binding force between the drug and the plasma protein after the drug is introduced into the body. In this study, we used ultrafiltration technology similar to the in vivo environment (excretion of drugs in the kidney) Enzyme inhibitors and their analogues