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为了解人工补碘前后人群甲状腺激素的水平 ,全面评价预防措施的效果 ,1996年和 1998年两次应用 RIA法 (双抗体法 )对克拉玛依市二个区 6 15名学生补碘前后血清游离甲状腺素 (FT4)和促甲状腺激素 (TSH)水平进行检测。结果表明 :克拉玛依区补碘前 FT4性甲低者为 17.9% ,补碘后为 7.1% ;独山子补碘前为 16 .8% ,补碘后为 9.7% ,两个区补碘后 FT4性甲低率均较补碘前为低 ,有显著性差异 (χ21 =4.98,P<0 .0 5 ;χ22 =4.2 6 ,P<0 .0 5 ) ;甲状腺肿大组学生 FT4性甲低率较非肿大组高 (χ2 =45 .18,P<0 .0 1) ;TSH异常率肿大组较非肿大组高 (χ2 =2 6 .2 7,P<0 .0 1) ,表明补碘前学生无论甲状腺肿大者还是非肿大者其甲状腺功能均有不同程度的减退 ,甲状腺肿大者最为明显 ,补碘后 ,甲状腺功能减退得到显著改善 ;TSH值异常者补碘前后亦有显著性差异。证明补碘干预措施是防治甲状腺功能减退的积极有效的方法。
In order to understand the effect of preventive measures before and after artificial iodine supplement, to evaluate the effect of preventive measures in an all-round way, the serum free thyroid gland before and after supplementing iodine in 615 students in two districts of Karamay was detected by RIA method (double antibody method) in 1996 and 1998 (FT4) and thyroid stimulating hormone (TSH) levels were detected. The results showed that the FT4 hypothyroidism in the Karamay region was 17.9% before iodine supplementation and 7.1% after iodine supplementation. The Dushanzi was 16.8% before iodine supplementation and 9.7% after iodine supplementation. The FT4 The rates of hypothyroidism and hypothyroidism were significantly lower than those before iodine supplementation (χ21 = 4.98, P <0.05; χ22 = 4.2 6, P <0.05) (Χ2 = 45.18, P <0.01). The rate of TSH abnormality in the enlarged group was higher than that in the non-enlarged group (χ2 = 26.27, P <0.01) The results showed that before thyme iodine supplement, both thyroid function and thyroid enlargement decreased to some extent, thyroid enlargement was the most obvious. After iodine supplementation, hypothyroidism was significantly improved. Before and after iodine supplement There are also significant differences. It is proved that iodine supplement intervention is a positive and effective method to prevent hypothyroidism.