对8名健康年轻受试者,单剂量肌肉注射庆大霉素8万u 及两周后在同部位肌注庆大霉素8万u 加青霉素80万u,用荧光偏振免疫分析方法分别测得体内庆大霉素血清浓度。由此获得的两组药物动力学参数在同一个体中差异较小。吸收速率常数(Ka)、消除速率常数(K)、达峰时间(Tp)、药一时曲线下面积(AUC)等经统计处理P>0.05,结果表明青霉素对庆大霉素的药物动力学性质无显著影响。 Eight healthy young subjects, a single dose of gentamicin 80 000 u and two weeks after the same site intramuscular injection of gentamicin 80 000 u plus penicillin 800 000 u, using fluorescence polarization immunoassay were measured In vivo gentamicin serum concentrations. The pharmacokinetic parameters of the two groups thus obtained are less different in the same individual. Absorption rate constants (Ka), elimination rate constant (K), peak time (Tp), drug under the curve area (AUC) and other statistical treatment P> 0.05, the results show that penicillin gentamicin pharmacokinetic properties No significant effect.