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目的探讨孕中期唐氏综合征产前筛查血清标志物AFP及游离β-hCG MoM值分布与孕妇年龄的关系。方法根据孕妇年龄分组,对各组血清标志物MoM值分布进行描述统计分析,取其中中位数和众数两指标与孕妇年龄分别进行相关分析,并对各相关系数进行显著性检验。结果 AFP MoM值中位数和众数与孕妇年龄之间均存在显著性负相关,β-hCG MoM值中位数和众数与孕妇年龄之间,β-hCG MoM/AFP MoM值中位数和众数与孕妇年龄之间均不存在显著性相关性。结论 AFP MoM值中位数和众数与孕妇年龄之间均存在显著性负相关,β-hCG MoM值中位数和众数与孕妇年龄之间,β-hCG MoM/AFP MoM值中位数和众数与孕妇年龄之间也均不存在显著性相关性。
Objective To investigate the relationship between the prenatal screening serum markers AFP and free β-hCG MoM distribution and the age of pregnant women in the second trimester of pregnancy. Methods According to the age of pregnant women grouping, the distribution of MoM values of serum markers in each group were described and analyzed statistically. Correlation analysis was made between the two indexes of median and mode, and the age of pregnant women respectively, and the correlation coefficients were tested. Results There was a significant negative correlation between median and mean AFP MoM values and age of pregnant women. The median MoM MoM / AFP MoM / β-hCG MoM median and mean and the median age of pregnant women There was no significant correlation between the pattern and the age of pregnant women. Conclusions There is a significant negative correlation between the median and mode of AFP MoM value and the age of pregnant women. The median of MoM / β-hCG MoM / There was also no significant correlation between the pattern and the age of pregnant women.