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目的采用紫外-可见分光光度法测定乳酸亚铁胶囊的溶出度。方法以0.1 mol·L~(-1)盐酸溶液为溶出介质,篮法,转速为50 r·min~(-1),30 min时取样进行显色,在510 nm处测定吸光度。结果亚铁离子检测浓度的线性范围为0.66~4.64μg·m L~(-1)(r=0.9999);平均回收率为99.98%,RSD=0.23%(n=9);3批样品在不同的溶出介质中,30 min的溶出量均达80%以上。结论所用方法准确、可靠,可用于测定该制剂的溶出度。
Objective To determine the dissolution of ferrous lactate capsules by UV-Vis spectrophotometry. Methods 0.1 mol·L ~ (-1) hydrochloric acid solution was used as the dissolution medium. The basal rotation speed was 50 r · min -1. Samples were taken for color development at 30 min and the absorbance was measured at 510 nm. Results The linear range of ferrous ion concentration was 0.66 ~ 4.64μg · m L -1 (r = 0.9999). The average recovery was 99.98%, RSD was 0.23% (n = 9) Of the dissolution medium, 30 min dissolution reached more than 80%. Conclusion The method used is accurate and reliable and can be used to determine the dissolution of the preparation.