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本文旨在研究肝硬化病人血清甲胎蛋白(AFP)出现的方式,并在伴有血清AFP升高的病例中,评价HB_sAg的阳性率、肝组织学表现、以及肝细胞癌的发病率与病死率。方法:取159例肝硬化患者的血清标本,用放射免疫法或被动血凝法检验AFP。其中25例AFP阳性及36例AFP阴性病例的血清标本,用放射免疫法检测HB_sAg;用免疫电镜检测Dane颗粒,后者超过总颗粒数1％被定为Dane颗粒阳性。AFP浓度>20ng/ml作为阳性。将21例AFP阳性及36例AFP阴性病例的肝组织病理学表现进行比较,组织标本用H.E.染色,以银浸透对网状纤维染色。每例根据病变的严重度作
This paper aims to study the appearance of serum alpha-fetoprotein (AFP) in patients with cirrhosis, and evaluate the positive rate of HB_sAg, histological features of liver, and the incidence and mortality of hepatocellular carcinoma in patients with elevated serum AFP. rate. METHODS: Serum samples from 159 patients with liver cirrhosis were used to examine AFP by radioimmunoassay or passive hemagglutination. Serum samples of 25 patients with AFP-positive and 36 AFP-negative cases were tested for HB_sAg by radioimmunoassay. Dane particles were detected by immunoelectron microscopy. The latter, which exceeded 1% of total particles, was determined to be positive for Dane particles. AFP concentrations >20 ng/ml as positive. The pathological features of liver tissue in 21 cases of AFP-positive and 36 cases of AFP-negative cases were compared. Tissue specimens were stained with H.E. and silver-soaked reticular fibers were stained. Each case is based on the severity of the lesion