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[目的]比较结肠癌根治术后辅助腹腔化疗与辅助静脉化疗的毒副反应、复发转移情况及2年生存率。[方法]79例结肠癌根治性手术后进行辅助化疗,分为腹腔化疗组41例,静脉化疗组38例,使用方案均为5-Fu+CF。[结果]全部病例均完成6次化疗周期,并且随诊2年。腹腔化疗组胃肠道毒副反应占75.6%,骨髓抑制占65.9%,肝功能异常占70.7%,肾功能异常占17.1%,神经系统损害占4.9%,腹腔局部复发占43.9%,肝脏转移占9.8%,肺转移占4.9%,2年生存率68.3%;静脉化疗组胃肠道毒副反应占92.1%,骨髓抑制占89.5%,肝功能异常占81.6%,肾功能异常占47.4%,神经系统损害占7.9%,腹腔局部复发占57.9%,肝脏转移占23.7%,肺转移占2.6%,2年生存率60.5%。[结论]结肠癌根治性手术后辅助腹腔化疗较辅助静脉化疗毒副反应小,患者的治疗顺应性更高,并且能有效地降低腹腔及肝脏复发转移的发生率。
[Objective] To compare the side effects, recurrence and metastasis and 2-year survival rate of adjuvant intraperitoneal chemotherapy and adjuvant chemotherapy after radical resection of colon cancer. [Method] Adjuvant chemotherapy was performed in 79 patients with colon cancer undergoing radical surgery. The patients were divided into intraperitoneal chemotherapy group (41 cases) and intravenous chemotherapy group (38 cases). All the regimens were 5-Fu + CF. [Results] All the cases completed 6 cycles of chemotherapy and were followed up for 2 years. Abdominal chemotherapy group gastrointestinal side effects accounted for 75.6%, bone marrow suppression accounted for 65.9%, liver function abnormalities accounted for 70.7%, renal dysfunction accounted for 17.1%, nervous system damage accounted for 4.9%, abdominal recurrence accounted for 43.9%, liver metastasis 9.8%, pulmonary metastasis accounted for 4.9%, 2-year survival rate 68.3%; gastrointestinal side effects of intravenous chemotherapy accounted for 92.1%, bone marrow suppression accounted for 89.5%, liver dysfunction accounted for 81.6%, renal dysfunction accounted for 47.4% System damage accounted for 7.9%, abdominal recurrence accounted for 57.9%, liver metastasis accounted for 23.7%, lung metastases accounted for 2.6%, 2-year survival rate of 60.5%. [Conclusion] Adjuvant intraperitoneal chemotherapy after adjuvant intraperitoneal chemotherapy for colorectal cancer is less toxic than adjuvant intravenous chemotherapy, and the treatment compliance of patients with colorectal cancer is higher, and the incidence of recurrence and metastasis in abdominal cavity and liver can be effectively reduced.