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目的:分析辅助生殖技术(ART)相关急腹症的临床特点以及与胚胎移植日血清性激素水平的关系。方法:回顾分析2009年1月-2013年12月间,5 020个体外受精-胚胎移植(IVF-ET)助孕周期中急腹症的发生率及其临床特点,化学发光法检测血清雌二醇、孕酮、促黄体生成素、卵泡刺激素水平。分析急腹症的发生与胚胎移植日血清性激素水平的关系。结果:5 020个IVF助孕周期中女方急腹症发生率为3.24%(163例),急腹症组的获卵数和早期流产率明显高于对照组(P<0.05),两组患者平均年龄、移植胚胎数、妊娠率均没有明显差异(P>0.05)。急腹症组胚胎移植日血清雌二醇水平明显高于对照组(P<0.05),但孕酮、促黄体生成素及卵泡刺激素水平没有明显差异(P>0.05)。结论:辅助生殖技术并发急腹症可能导致早期流产率增高,胚胎移植日血清高水平的雌激素是导致辅助生殖技术并发急腹症的高危因素之一。
OBJECTIVE: To analyze the clinical features of ART related acute abdomen and its relationship with serum sex hormone levels on embryonic day. Methods: The incidence and clinical features of acute abdomen in 5 020 in vitro fertilization-embryo transfer (IVF-ET) during pregnancy period were retrospectively analyzed from January 2009 to December 2013. Chemiluminescence method was used to detect serum estradiol Alcohol, progesterone, luteinizing hormone, follicle stimulating hormone levels. To analyze the relationship between the incidence of acute abdomen and serum sex hormone levels on the day of embryo transfer. Results: The incidence rate of female acute abdomen in 5 020 IVF pregnancy cycles was 3.24% (163 cases). The number of oocytes and the rate of early miscarriage in acute abdomen group were significantly higher than those in control group (P <0.05) There was no significant difference in average age, number of embryos transferred and pregnancy rate (P> 0.05). Serum estradiol levels were significantly higher on the day of embryo transfer in acute abdomen group than in the control group (P <0.05), but there was no significant difference in progesterone, luteinizing hormone and follicle stimulating hormone (P> 0.05). Conclusions: Assisted reproductive technology combined with acute abdomen may lead to an increase of early abortion rate. High serum estrogen level on embryo transfer day is one of the risk factors of assisted abortion in acute abdomen.