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目的探讨参芎葡萄糖注射液联合脑蛋白水解物治疗急性脑梗死的疗效及对神经功能缺损和血液流变学的影响。方法抽取2015年1月-2016年3月河南大学淮河医院接收的62例急性脑梗死患者,随机分为观察组与对照组,各31例。对照组静脉滴注脑蛋白水解物治疗,观察组采用脑蛋白水解物与参芎葡萄糖注射液联合治疗。对比两组临床疗效及治疗前后神经功能缺损评分和血液流变学各指标水平变化情况。结果观察组治疗总有效率为87.1%,对照组为64.5%,两组比较差异有统计学意义(P<0.05);治疗前两组神经功能缺损评分比较差异无统计学意义(P>0.05),经治疗,观察组显著优于对照组,差异有统计学意义(P<0.05);治疗前两组血液流变学各指标水平比较差异无统计学意义(P>0.05),经治疗,两组各指标均有所改善,且观察组纤维蛋白原及红细胞压积水平明显优于对照组,差异有统计学意义(P<0.05)。结论在脑蛋白水解物治疗基础上对急性脑梗死患者加用参芎葡萄糖注射液疗效显著,可显著提高患者神经功能,改善血液流变学相关指标,提高临床疗效。
Objective To investigate the curative effect of Shenxiong and dextrose injection combined with brain protein hydrolyzate on acute cerebral infarction and its influence on neurological deficits and hemorheology. Methods Sixty-two patients with acute cerebral infarction received from Huaihe Hospital of Henan University from January 2015 to March 2016 were randomly divided into observation group and control group, with 31 cases in each group. Control group intravenous brain protein hydrolyzate treatment, the observation group using brain protein hydrolyzate and Shenxiong glucose injection combined treatment. The curative effect of the two groups were compared and the changes of neurological deficit score and hemorheology indexes were observed before and after treatment. Results The total effective rate was 87.1% in the observation group and 64.5% in the control group, with significant difference between the two groups (P <0.05). There was no significant difference in neurological deficit scores between the two groups before treatment (P> 0.05) , After treatment, the observation group was significantly better than the control group, the difference was statistically significant (P <0.05); before treatment, there was no significant difference in hemorheology indexes between the two groups (P> 0.05) Group indicators improved, and the observation group fibrinogen and hematocrit levels were significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion On the basis of brain protein hydrolyzate, the effect of adding Shenxiong glucose injection on patients with acute cerebral infarction is significant, which can significantly improve the neurological function, improve the indexes of hemorheology and improve the clinical curative effect.