佐匹克隆(zopiclone)(图1)是第一个应用于精神治疗的吡咯环类新药,它具有类似苯二氮(艹卓)类高效低毒的药理作用,并认为可与在苯二氮(艹卓)受体结合成复合物或紧密地与这个复合物键合。 在动物实验中,尽管佐匹克隆具有抗惊厥、肌弛缓、抗焦虑等作用,但它更多作为催眠药使用,因为它有显著的镇静作用。在临床试验中,佐匹克隆(常用7.5mg)与硝基 Zopiclone (Figure 1) is the first pyrrole-ring drug to be used in psychiatric treatment. It has pharmacological effects similar to benzodiazepines with high potency and low toxicity and is believed to work in combination with benzodiazepines (艹 Zhuo) receptor complexed or complexed with this complex. In animal experiments, although zopiclone has anticonvulsant, muscle relaxation, anti-anxiety and other effects, but it is more used as a hypnotic because it has a significant sedative effect. In clinical trials, zopiclone (7.5 mg commonly used) and nitro