论文部分内容阅读
目的探讨成人乙型病毒性肝炎(乙肝)疫苗接种后无应答者的免疫对策。方法选择浙江省湖州市南浔区免疫无应答人群免疫前检测乙肝表面抗原(HBsAg)和乙肝表面抗休(抗-HBs)均阴性的健康人群,按“0,1,3”;“0,1,6”;“0,1,12”程序完成3针20μg重组酵母乙肝疫苗免疫后检测乙肝抗-HBs几何抗体平均浓度(GMC)<10IU/L的免疫失败者,接种1剂次60μg乙肝疫苗后1个月,检测抗-HBs。结果 323例免疫失败者完成再免后抗-HBs阳性率为92.6%,GMC为835 IU/L。结论成人乙肝疫苗接种后免疫失败者,通过加大乙肝疫苗剂量,再次接种1剂次60μg乙肝疫苗可大幅度提高抗-HBs阳转率,效果优于再次接种10μg或20μg乙肝疫苗。
Objective To investigate the immunization strategy of non-responders after adult hepatitis B (HB) vaccination. Methods The healthy non-responders in Nanxun District of Huzhou City, Zhejiang Province before immunization were tested for HBsAg and anti-HBs (anti-HBs) negative healthy population, according to “0,1,3 ”; 0,1,6 “;” 0,1,12 "program to complete the 3-pin 20μg recombinant yeast Hepatitis B vaccine to detect anti-HBs geometric antibody average antibody concentration (GMC) <10IU / L immune failure, vaccination One dose of 60 μg hepatitis B vaccine one month after the test for anti-HBs. Results The positive rate of anti-HBs was 92.6% and the GMC was 835 IU / L in 323 immune failure patients. Conclusions Adult immunized hepatitis B vaccination failed, by increasing the dose of hepatitis B vaccine, once again vaccinated a dose of 60μg hepatitis B vaccine can significantly improve anti-HBs positive rate, the effect is better than re-vaccinated 10μg or 20μg of hepatitis B vaccine.