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目的:探讨虎杖口服液对慢性阻塞性肺疾病伴肺动脉高压患者血流动力学的影响。方法:选取慢性阻塞性肺疾病伴肺动脉高压的患者60例,随机分为对照组(32例)和虎杖组(28例)。对照组给予常规吸氧、抗感染、化痰、平喘等治疗,虎杖组在常规治疗基础上给予虎杖口服液,共用药21天,分别测定治疗前及治疗后的肺动脉压、心率、体循环平均压。结果:对照组的肺动脉压无明显变化(P>0.05),心率有显著改善(P<0.01),体循环平均压无明显改善(P>0.05);虎杖组的肺动脉压有显著改善(P<0.05),心率有显著改善(P<0.01),且较对照组无明显差异(P>0.05),体循环平均压无明显改善(P>0.05)。结论:虎杖口服液能降低COPD伴肺动脉高压患者的肺动脉压力,从而延缓肺动脉高压的进展。
Objective: To investigate the effects of Huzhang Oral Liquid on hemodynamics in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Methods: Sixty patients with chronic obstructive pulmonary disease and pulmonary hypertension were randomly divided into control group (n = 32) and Polygonum cuspidatum group (n = 28). The control group was given routine oxygen inhalation, anti-infective, phlegm, asthma and other treatment, the Polygonum cuspidatum group was given on the basis of routine treatment Huzhu oral liquid, for 21 days, were measured before and after treatment of pulmonary arterial pressure, heart rate, Pressure Results: There was no significant change in pulmonary arterial pressure in the control group (P> 0.05), heart rate was significantly improved (P <0.01), and mean systemic pressure was not significantly improved (P> 0.05) Heart rate was significantly improved (P <0.01), and no significant difference compared with the control group (P> 0.05), no significant improvement in the mean body pressure (P> 0.05). Conclusion: Polygonum cuspidatum oral liquid can decrease pulmonary artery pressure in patients with COPD and pulmonary hypertension and delay the progression of pulmonary hypertension.