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实验组大鼠每日量按3.0毫升/100克连续灌给灵芝浸膏14天。对照组大鼠灌给等量的蒸溜水。按照Miles的方法,将两组大鼠烫伤,面积占体表面积的50％。于烫后的第5个小时,从全部存活的动物的心尖部切取心肌组织块。经固定,切片,在电子显微镜下观察到对照组动物的心肌线粒体的超微结构发生异常的改变。线粒体明显肿胀,嵴排列紊乱,有些嵴断裂或消失,并有髓鞘样结构畸形出现。全部线粒体均受到损害。而实验组动物的心肌线粒体的超微结构保持稳定状态,线粒体的结构均正常。实验结果提示:灵芝浸膏对心肌线粒体具有膜稳定的作用,对“休克心”有一定的保护性作用。
The rats in the experimental group were given a daily dose of 3.0 ml/100 g for 14 days. Rats in the control group were given equal amounts of distilled water. The two groups of rats were burned according to the method of Miles, and the area occupied 50% of the body surface area. At the 5th hour after the scald, myocardial tissue blocks were cut from the apex of all surviving animals. After fixation, sectioning, the abnormal ultrastructural changes of myocardial mitochondria in the control animals were observed under an electron microscope. The mitochondria are obviously swollen, the ridges are disorderly arranged, some ridges are broken or disappeared, and the myelin-like structure is abnormal. All mitochondria were damaged. However, the ultrastructure of myocardial mitochondria in experimental animals remained stable, and the structure of mitochondria was normal. The experimental results suggest that Ganoderma extract has a membrane-stabilizing effect on myocardial mitochondria and has a protective effect on “shock heart”.