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目的:探讨益气活血煎剂抗肝纤维化的作用。方法:制备大鼠免疫性肝纤维化模型,分为对照组、病理组和中药组,观察肝脏病理变化,治疗组于治疗前、治疗1个月和3个月共取肝组织3次,分别进行电镜和光镜观察,比较治疗前后肝脏病变情况。蛄果:灌喂治疗1个月后治疗组与造模组肝纤维化程度无明显变化(P>0.05),2个月后则差异显著(P<0.05)。结论:益气养血、祛痰化痰、软坚通络中草药煎剂治疗2个月,能明显减轻肝纤维化程度。
Objective: To investigate the effect of Yiqihuoxue decoction on hepatic fibrosis. METHODS: The rat model of immune hepatic fibrosis was prepared and divided into control group, pathological group and traditional Chinese medicine group. Liver pathological changes were observed. The treatment group received liver tissue three times before treatment, one month and three months treatment, respectively. Electron microscopy and light microscopy were performed to compare the liver lesions before and after treatment. Capsule: There was no significant change in hepatic fibrosis between the treatment group and the model group (P>0.05) after one month of feeding, and there was a significant difference after two months (P<0.05). Conclusion: The herbal medicine decoction of Yiqi Yangxue, Huatan Huayu, Ruanjian Tongluo for 2 months can significantly reduce the degree of hepatic fibrosis.