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目的:研究外阴白色病变组织中血管内皮生长因子(VEGF)和人原始造血细胞抗原(CD34)的表达,从而进一步探讨外阴白色病变的发病机制。方法:应用免疫组化方法观察62例外阴白色病变(包括外阴鳞状上皮增生32例,外阴硬化性苔藓30例)组织中的VEGF、CD34表达情况,10例正常外阴皮肤组织作为对照。结果:外阴硬化性苔藓(LS组)的VEGF的表达和微血管数目(MVD值)均显著低于正常外阴皮肤组及外阴鳞状上皮增生(SH组),差异有统计学意义(P<0.05);SH组与正常外阴组织相比差异无统计学意义(P>0.05),VEGF的表达与MVD计数在LS中存在正相关。结论:外阴硬化性苔藓组织中VEGF表达减少,引起MVD值显著减少,可能是外阴硬化性苔藓的发病机制之一;外阴鳞状上皮增生组织中VEGF的表达和MVD值无明显改变,微血管结构功能障碍可能是外阴鳞状上皮增生的发病机制之一。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and human hematopoietic cell antigen (CD34) in vulvar and white lesions, so as to further explore the pathogenesis of white lesions in vulva. Methods: The expressions of VEGF and CD34 in 62 cases of vulvar white lesions (including 32 cases of vulvar squamous hyperplasia and 30 cases of vulva vulgaris) were observed by immunohistochemistry. Ten cases of normal vulvar skin tissue were used as control. Results: The expression of VEGF and the number of microvessel (MVD) in LS group were significantly lower than those in normal vulvar skin group and vulvar squamous epithelial group (SH group) (P <0.05) There was no significant difference between SH group and normal vulva tissue (P> 0.05). There was a positive correlation between VEGF expression and MVD count in LS. CONCLUSIONS: The decrease of VEGF expression in vulvar vulgaris tissues may cause the decrease of MVD, which may be one of the pathogenesis of vulvar vulvar lichenification. The expression of VEGF and MVD in vulvar squamous epithelium have no obvious changes, and the structure and function of microvessels Obstacles may be one of the pathogenesis of vulvar squamous cell hyperplasia.