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评价２０％甘露醇、７．５％盐水及综合药物治疗（５０％葡萄糖，速尿，地塞米松）对高原急性创伤性脑水肿的治疗效果，探讨在野战环境下治疗高原创伤性脑水肿的可行方案及治疗时机。在减压舱中模拟海拔４０００ｍ高度，制作创伤性脑损伤动物模型，通过测量脑组织水含量、伊文思蓝含量，同时作头颅ＣＴ扫描及光镜观察脑损伤灶的病理变化，以评价脑损伤后不同时间、不同治疗方法对高原创伤性脑水肿的治疗效果。结果表明各治疗组对脑水肿均有一定的治疗作用。其中，甘露醇组和综合治疗组效果优于高渗盐水组；伤后２ｈ用药组优于４ｈ及８ｈ用药组。结果提示甘露醇依然是治疗高原创伤性脑水肿的有效药物，高渗盐水及综合药物治疗对高原创伤性脑水肿也有明显疗效；治疗时间越早，效果越好。在治疗高原创伤性脑水肿的同时，应重视高原环境对心、肺等重要脏器的损害，施以综合治疗方可获得良好效果
To evaluate the therapeutic effect of 20% mannitol, 7.5% saline and general medical therapy (50% dextrose, furosemide and dexamethasone) on acute traumatic brain edema in the plateau, and to investigate the therapeutic effect of 20% mannitol, 7.5% saline and traumatic brain edema Feasible options and timing of treatment. The altitude of 4000m was simulated in the decompression cabin to make the animal model of traumatic brain injury. By measuring the water content of brain tissue and the content of Evans blue, the brain lesions were evaluated by cranial CT scan and light microscope. After different time, different treatment methods for the treatment of traumatic brain edema. The results show that all treatment groups have a certain therapeutic effect on cerebral edema. Among them, the effect of mannitol group and comprehensive treatment group was better than that of hypertonic saline group; the treatment group 2h after wounding was better than that of 4h and 8h treatment group. The results suggest that mannitol is still an effective drug for the treatment of traumatic brain edema in the plateau. Hypertonic saline and synthetic drug therapy also have a significant effect on traumatic brain edema in the plateau. The earlier the treatment is, the better the effect is. In the treatment of traumatic brain edema plateau at the same time, should pay attention to the plateau environment on the heart, lung and other important organs damage, combined treatment can be obtained good results