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目的：探讨甲磺酸培氟沙星的临床应用及其不良反应。方法：采用随机分组、单盲法对照、开放试验设计。结果：甲磷酸培氧沙星与氧氟沙星口服随机对照治疗呼吸系、泌尿系、消化系及皮肤软组织感染共100例，疗程10d－14d，甲磷酸培氟沙星组总的有效率和细菌清除率分别为96．0％、95．1％，不良反应率为6．0％，与对照组相比无显著性差异。结论：甲磷酸培氟沙星抗菌谱广，生物利用度高，不良反应少，是值得临床推广使用的新型抗菌药物。
Objective: To investigate the clinical application of pefloxacin mesylate and its adverse reactions. Methods: Randomized, single-blind control, open trial design. Results: 100 cases of respiratory tract, urinary tract, digestive system and skin and soft tissue infections were randomly controlled by oral administration of pefloxacin and ofloxacin. The total effective rate of pefloxacin-methyl phosphate group Bacterial clearance rate was 96.0%, 95.1%, adverse reaction rate was 6.0%, compared with the control group no significant difference. Conclusion: Pefloxacin phosphate antibacterial spectrum wide, high bioavailability, fewer adverse reactions, is worth promoting the use of new antibacterial drugs.