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目的：评价氯吡格雷对非ST段抬高冠脉综合征（ NSTEACS ）患者炎症因子及预后的影响。方法将我院收治的120例NSTEACS患者随机分为氯吡格雷联合阿司匹林组（观察组）和阿司匹林组（对照组），每组60例，分别于治疗前和治疗4周后检测炎症因子水平、心功能指标。结果治疗前，2组炎症因子水平、心功能指标的差异无统计学意义；治疗4周后，观察组和对照组的C-反应蛋白（CRP）（4.2±0.8） vs （7.1±1.3）mg· L-1，肿瘤坏死因子（TNF -α）（39.6±9.4） vs （66.9±11.4） pg· L-1，观察组均低于对照组；舒张早期充盈峰速度（E 峰）（76.4±14.9） vs （72.1±13.6）cm· s-1，E/A值（1.4±0.2） vs （1.3±0.2），左心室射血分数（LVEF）（69.3±11.3）％ vs （64.1±7.5％），左心室舒张末期直径（LVEDD）（58.3±7.8） vs （54.1±8.7），观察组均高于对照组。E峰、E/A值、LVEF、LVEDD均与CRP、TNF-α含量呈负相关。结论氯吡格雷能够有效的降低炎症因子水平、改善远期心功能。“,”Objective To study the effect of clopidogrel on inflammatory factors and prognosis of patients with non ST segment elevationacute coro-nary syndrome ( NSTEACS ).Methods One hundred and twenty pa-tients with NSTEACS in our hospital were enrolled and randomly divided into observation group ( given aspirin combined with clopidogrel ) and control group ( only given aspirin ).Inflammatory factor level and heart function index were detected at pretreatment and 4-week treatment , re-spectively.Results Before treatment , the differences of inflammatory factor level and heart function indexe of two groups had no statistical sig-nificance;after 4 -week treatment , the levels of C -reactive protein ( CRP) ( 4.2 ±0.8 ) vs ( 7.1 ±1.3 ) mg · L-1 and tumor necrosis factor-α(TNF-α) (39.6 ±9.4) vs (66.9 ±11.4) pg· L-1 in ob-servation group were lower than those in control group.The values of E peak (76.4 ±14.9 ) vs (72.1 ±13.6 ) cm· s-1 , E/A (1.4 ±0.2 ) vs ( 1.3 ±0.2 ) , LVEF ( 69.3 ±11.3 )% vs ( 64.1 ±7.5 )%, and LVEDD (58.3 ±7.8 ) vs (54.1 ±8.7 ) in observation group were higher than those in control group.The values of E peak , E/A value, LVEF, LVEDD had negative correlation with the levels of CRP and TNF -α.Conclusion Clopidogrel can effectively decrease the levels ofinflammatory factors and improve long -term heart function of patients with NSTEACS.